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There is no vaccine for hepatitis C, therefore prevention of HCV infection depends upon reducing the risk of exposure to the virus in health-care settings and in higher risk populations, for example, people who inject drugs, and through sexual contact.
In April 2016, WHO updated its "Guidelines for the screening, care and treatment of persons with chronic hepatitis C".
About 15–45% of infected persons spontaneously clear the virus within 6 months of infection without any treatment. The most affected regions are WHO Eastern Mediterranean and European Regions, with the prevalence of 2.3% and 1.5% respectively.
Although the production cost of DAAs is low, these medicines remain very expensive in many high- and upper middle-income countries.Conversely, among all HIV-infected persons, the prevalence of anti-HCV was 6.2%.Liver diseases represent a major cause of morbidity and mortality among persons living with HIV.Sofosbuvir, daclatasvir and the sofosbuvir/ledipasvir combination are part of the preferred regimens in the WHO guidelines, and can achieve cure rates above 95%.These medicines are much more effective, safer and better-tolerated than the older therapies.Depending on the country, hepatitis C virus infection can be concentrated in certain populations (for example, among people who inject drugs) and/or in general populations.